报告题目（Title）： A large-scale genome-wide association study in the human pathogen Streptococcus pyogenes with a point-mutation switch system
报 告 人（Speaker）： 暴云娟 教授 （湖北大学生命科学学院）
Robust characterization of phenotype-genotype correlations in diseases is essential for precise diagnosis and treatments. The correlations are often complicated in infectious diseases caused by pathogenic bacteria due to rapid adaptation of pathogens to host environments through gaining diverse genetic variations.
Group A Streptococcus pyogenes (GAS) is a highly versatile infectious agent, causing diverse human diseases in a wide range of tissues and organs. The causative biomarkers associated with the diseases are still unclear. Using this human-pathogenic bacterium as a paradigm, we applied the genome-wide association study (GWAS) framework to identify genetic variations associated with distinct disease phenotypes among thousands of natural GAS isolates. We also performed statistical modeling and phylogenetic congruence tests to elucidate the evolutionary mechanisms underlying the association between the genotypes and phenotypes.